Modest Hypothermia Provides Partial Neuroprotection for Ischemic Neonatal Brain
نویسندگان
چکیده
منابع مشابه
Neuroprotection after infection-sensitized neonatal hypoxic-ischemic brain injury
s of the 51st Workshop for Pediatric Research 51st Workshop for Pediatric Research
متن کاملHypothermia in neonatal hypoxic-ischemic encephalopathy (HIE).
Neonatal hypoxic-ischemic encephalopathy (HIE) significantly affects neurodevelopment in infants and is also considered as an important cause of neonatal deaths worldwide. Medical research is being focused worldwide for the development of therapeutic avenues but it is still managed by supportive care. The latest studies in the above field have shown the efficacy of prolonged cooling of neonate'...
متن کاملXenon and hypothermia combine to provide neuroprotection from neonatal asphyxia.
Perinatal asphyxia can result in neuronal injury with long-term neurological and behavioral consequences. Although hypothermia may provide some modest benefit, the intervention itself can produce adverse consequences. We have investigated whether xenon, an antagonist of the N-methyl-D-aspartate subtype of the glutamate receptor, can enhance the neuroprotection provided by mild hypothermia. Cult...
متن کاملSystemic hypothermia--a "cool" therapy for neonatal hypoxic-ischemic encephalopathy.
Hypoxic–ischemic encephalopathy is an important cause of death and disability in full-term infants. The incidence of moderate or severe hypoxic– ischemic encephalopathy has remained essentially unchanged over the past 20 years, at 1.5 to 2 per 1000 live births in the United States. Approximately 15 to 20 percent of these infants will die, and 20 to 25 percent of those who survive will be disabl...
متن کاملBrain Hypothermia Therapy for Neonatal Hypoxic-ischemic Encephalopathy with a Severely Elevated Serum Creatine Kinase Level.
Several studies have shown that brain hypothermia therapy (BHT) after neonatal hypoxic-ischemic encephalopathy (HIE) can improve neurodevelopmental outcomes. However, there have been no reports of the neurodevelopmental outcomes for the infant with a serum creatine kinase (CK) level above 20,000 IU/L in association with neonatal HIE. We report a female infant with a very high serum CK level (26...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1994
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199404000-00010